Written by world authorities on the subject, this reference comprehensively covers every aspect of colorectal cancer. Addressing the molecular mechanisms, genetics, identification, and therapy of disease, this guide covers new pharmaceutical developments, current screening protocols, and modern methods of disease management by specialists at renowned institutions such as the Royal Marsden Hospital, the Memorial Sloan Kettering Cancer Center, and the Vanderbilt-Ingram Cancer Center.

Now fully revised and in its fourth edition, the Oxford Handbook of Oncology has been the essential go-to guide for students and practitioners in oncology for over a decade. The scientific basis and diagnosis of cancers is covered, as well as drugs, biomarkers, and the presentation and psychosocial aspects of oncology. Concise, practical, and comprehensive, there is no better companion for both common conditions and challenging emergencies. The field of oncology has surged forward since the last edition was published and the Oxford Handbook of Oncology has been fully revised and updated to reflect these recent advances so you can be sure that the vital information you need is in your hands. This handbook incorporates changes such as the understanding of the science of cancer, novel therapies in breast, lung, renal, and melanoma, molecular sub-classification of common solid cancers, personalized therapy approaches, new agents in hard to treat cancers, the benefits of new technologies in radiotherapy, and the emerging data on the importance of the immune response. Written by experts in the field to ensure that it is grounded in real life clinical practice, this handbook provides a concise guide to all aspects of oncology for all students, nurses, and junior faculty responsible for the care of cancer patients, while also providing further reading and highlighting areas of controversy for those who need a more detailed understanding.

This book addresses a void in the synthetic archaeological knowledge of the North Pacific by enabling a more informed evaluation of North Pacific Rim seafaring hypotheses. It answers questions about intra- and inter-regional relationships in the evolution of maritime adaptations throughout the region. The authors collectively address evidence of aquatic activities during the Late Pleistocene and Holocene in the Sea of Japan, Sea of Okhotsk and adjacent coastal areas of Korea, Japan, Sakhalin Island, the Kurile Islands and the Russian Far East with syntheses placing the region into a larger North Pacific context. This examination provides essential data on human modes of terrestrial adaptation and the transition to maritime lifeways over the last 40,000 years. It also provides a much-needed foundation to better understand the peopling of the New World 17,000 years ago, either by a pedestrian transit or through the use of watercraft, or more likely a combination of the two. As one of the first publications on the prehistory of the maritime region of Northeast Asia provided in English, with contributions by leading Korean, Japanese, Russian, Canadian, European and US-based researchers of the region, this volume presents a means for archaeologists to assess proposed hypotheses pertaining to late Pleistocene and Holocene seafaring around the North Pacific Rim. It is an essential read for specialists in history, archaeology, behavioural ecology and maritime evolution.

San Clemente Island is a microcosm of California coastal archaeology from prehistoric through historic times-not only because of the extensiveness of its archaeological remains but because those remains have been so well preserved. In California Maritime Archaeology, the authors use the island as a platform to explore evidence of early seafaring, colonization, paleoenvironmental change, and cultural interaction along the California coast. They make a strong case that San Clemente island should be seen as a kind of "California archaeological Galapagos," offering an extraordinary variety of ancient life as well as surprising information about prehistoric hunter-gatherers of the northern Pacific. The authors' two decades of research have resulted in this rich cultural history that defies widespread assumptions about California's ancient maritime history.

Written by world authorities on the subject, this reference comprehensively covers every aspect of colorectal cancer. Addressing the molecular mechanisms, genetics, identification, and therapy of disease, this guide covers new pharmaceutical developments, current screening protocols, and modern methods of disease management by specialists at renowned institutions such as the Royal Marsden Hospital, the Memorial Sloan Kettering Cancer Center, and the Vanderbilt-Ingram Cancer Center.